Department of Neuropeptides

Head:

Aleksandra Misicka-Kęsik PhD, DSc. Prof.

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Secretary:

Teresa Żuławnik - phone: +48 22 60 86 599 

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Research Staff

  • Lidia Rudnicka MD, PhD, Prof., email:  This email address is being protected from spambots. You need JavaScript enabled to view it.,
  • Piotr Kosson VD, PhD, email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48  22 608 64 54
  • Jolanta Dyniewicz PhD, email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48  22 608 64 80
  • Patrycja Redkiewicz PhD, email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48 22 608 64 80
  • Piotr Lipiński PhD, email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48  22 608 64 54
  • Joanna Matalińska Msc, Eng, email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48 22 608 64 55/548
  • Anna Włuka-Stecka Msc, email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48 22 608 65 99

PhD Students:

  • Tatsiana Damps MD, email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48 22 608 64 55
  • Anna Laskowska MSc, email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48  22 608 64 55   
  • Adriana Muchowska MSc,  email: This email address is being protected from spambots. You need JavaScript enabled to view it., phone: +48  608  64 54

Technician:

  • Barbara Nowicka - phone: +48  22 608 64 80

Key Research themes

Neuropeptides are endogenous peptides that are synthesized and released by neuronal cells. Released peptides express broad spectrum of functions including transmission and modulation of nervous signals, carrying neurohormonal signals to other body tissues, regulation of immunological system activity, direct antimicrobial activities et cetera. Isolation of new neuropeptides and the knowledge of their biological functions have been significantly enhanced in recent years.  Limited biological barrier permeability, specific metabolism and structural flexibility are specific biochemical and physico-chemical properties of peptides that differentiate them from other biologically active compounds. Their bio-pharmacological properties and cost of chemical syntheses for years limited interest in peptides as potential medicines. Recent progress in medicinal chemistry opens new avenue for development of new medicines based on neuropeptides.

Neuropeptide Department is an interdisciplinary group gathering chemists, pharmacologists, biologists and medical doctors doing complementary work on structure-activity relationships of peptides with final prospective application of results in development of new generation of medicines.

Role of neuropeptides in pain transmission and modulation and development of possible new methods of pain control has been a major avenue of our scientific activities.

Nevertheless, recent interest and activities of our group on peptides is broader and include:

  • peptides in neuroprotection;
  • peptides in cancer;
  • peptides in skin functions and wound healing;
  • peptides in neurodegenerative diseases;
  • role of blood-brain barrier;

Current Collaborations:

  • Faculty of Chemistry, University of Warsaw, Warsaw, Poland
  • Institute of Nuclear Chemistry and Technology, Warsaw, Poland (Prof. Jan Cz. Dobrowolski, prof. Ewa Gniazdowska)
  • National Medicines Institute, Warsaw, Poland (Prof. Joanna Sadlej)
  • Medical University of Lodz, Lodz, Poland (Prof. Jakub Fichna)
  • Institute of Organic Chemistry Polish Academy of Science, Warsaw, Poland (Prof. Zofia Lipkowska)
  • Biological Research Institute, Hungarian Academy of Sciences, Szeged (Prof. István Krizbai, Prof. Sandor Benyhe)
  • University of Arizona, Tucson, USA (Yeon Sun Lee PhD, DSc)

 

Current projects:

  • Radiopharmaceuticals based on neurokinin-1 receptor antagonists for the diagnosis and therapy of a brain tumour - glioblastoma multiforme. NCN OPUS (Aleksandra Misicka-Kęsik PhD, DSc. Prof., collaboration with  Institute of Nuclear Chemistry and Technology)
  • Development of an NK1 receptor homology model based on the data concerning interspecies differences in ligand binding. NCN SONATA  (Piotr Lipiński PhD)
  • Design and synthesis of novel small-molecular NK1 receptor antagonists. (Jolanta Dyniewicz PhD).
  • Natural peptides and their analogues able to modulate viability of malignant melanoma cells. (Joanna Matalińska Msc, Eng)
  • The influence of biodegradable keratin  obtained from alpaca wool on wound healing in the rats with induced diabetes. (Adriana Muchowska MSc, Patrycja Redkiewicz PhD)

Recent publications (2016-2017):

  1. J. Dyniewicz, P.F.J. Lipiński, P. Kosson, A. Leśniak, M. Bochyńska-Czyż, A. Muchowska, D. Tourwé, S. Ballet, A. Misicka, A.W. Lipkowski Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds ACS Medicinal Chemistry Letters, 2017, 8 (1), 73-77.
  1. P. F. J. Lipiński, P. Szurmak SCRAMBLE’N’GAMBLE: A tool for fast and facile generation of random data for statistical evaluation of QSAR models. Chem. Pap. 2017, 71 (11), 2217–2232.
  1. P.F.J. Lipiński, J.Cz. Dobrowolski Substituent effect in theoretical ROA spectra. RSC Advances, 2016, 6 (47), 40760-40764. 
  1. P.F.J. Lipiński, M. Jarończyk, S. Ostrowski, J.Cz. Dobrowolski, J. Sadlej Conformation of six fentanyls revisited. Comput. Theor. Chem., 2016, 1086, 18–24.
  1. A.K. Laskowska, A.K. Puszko, P. Sosnowski, K. Różycki, P. Kosson, J. Matalińska, M. Durlik, A Misicka Opioid Tripeptides Hybridized with trans-1-Cinnamylpiperazine as Proliferation Inhibitors of Pancreatic Cancer Cells in Two- and Three-Dimensional in vitro Models. ChemMedChem, 2017, 12 (19), 1637-1644.
  1. T. Damps, A.K. Laskowska, T. Kowalkowski, M. Prokopowicz, A.K. Puszko, P. Sosnowski, J. Czuwara, M. Konop, K. Różycki, J.K. Borkowska, A. Misicka, L. Rudnicka The effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment. PLoS One 12(8):e0184034. (2017)
  1. M. Konop, D. Sulejczak, J. Czuwara, P. Kosson, A. Misicka, A.W. Lipkowski, L. Rudnicka The role of allogenic keratin-derived dressing in wound healing in a mouse model. Wound Repair and Regeneration, 2017, 25 (1), 62–74.
  1. B. Fedorczyk, P. F. J. Lipiński, D. Tymecka, A. K. Puszko, B. Wilenska, G. Y.Perret, A. Misicka, Conformational Latitude – Activity Relationship of KPPR Tetrapeptide Analogues toward Their Ability to Inhibit Binding of Vascular Endothelial Growth Factor 165 to Neuropilin-1. J. Pept. Sci. 2017, 23 (6), 445–454.
  1. K. Grabowska, A.K. Puszko, P.F.J. Lipiński, A.K. Laskowska, B. Wileńska, E. Witkowska, G.Y. Perret, A. Misicka Structure-activity relationship study of a small cyclic peptide H-c[Lys-Pro-Glu]-Arg-OH: a potent inhibitor of Vascular Endothelial Growth Factor interaction with Neuropilin-1. Bioorganic & Medicinal Chemistry, 2017, 25 (2), 597-602.
  1. D. Tymecka, P. F. J. Lipiński, B. Fedorczyk, A. Puszko, B. Wileńska, G. Y. Perret, A. Misicka Structure-activity relationship study of tetrapeptide inhibitors of the vascular endothelial growth factor a binding to neuropilin-1. Peptides 2017, 94, 25–32.
  1. M. Jarończyk,  P. F. J. Lipiński, J. C. Dobrowolski, J. Sadlej The FMO analysis of the molecular interaction of fentanyl derivatives with the μ-opioid receptor. Chem. Pap. 2017, 71 (8), 1429–1443.
  1. E. Szczepanska-Sadowska, T. Zera, S. Sosnowski,  A. Cudnoch-Jedrzejewska, A. Puszko, A. Misicka Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders. Current Drug Metabolism, 18( 4), 306-345 (2017)
  1. A. Wasilewski, A. Misicka, M. Sacharczuk, J. Fichna Prosecretory effect of loperamide in ileal and colonic mucosae of mice displaying high or low swim stress-induced analgesia associated with high and low endogenous opioid system activity. Neurogastroenterol Motility (2017), doi: 10.1111/nmo.13166.
  1. O. Krupska, A. Sarnowska, B. Fedorczyk, M. Gewartowska, A. Misicka, B. Zablocka, M. Beresewicz Ischemia/Reperfusion-Induced Translocation of PKCβII to Mitochondria as an Important Mediator of a Protective Signaling Mechanism in an Ischemia-Resistant Region of the Hippocampus. Neurochemical Research 42(8), 2392-2403 (2017).          
  1. K. Guillemyn, J. Starnowska, C. Lagard, J. Dyniewicz, E. Rojewska, J. Mika, NN. Chung, V. Utard, P. Kosson, A.W. Lipkowski, L. Chevillard, P. Arranz-Gibert, M. Teixidó, B. Megarbane, D. Tourwé, F. Simonin, B. Przewlocka, P.W. Schiller, S. Ballet Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain. Journal of Medicinal Chemistry 2016, 59 (8), 3777-3792.
  1. K. Grabowska, A.K. Puszko, P.F.J. Lipiński, A.K. Laskowska, B. Wileńska, E. Witkowska, A. Misicka Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1. Bioorganic & Medicinal Chemistry Letters, 2016, 26 (12), 2843-2846.
  1. M. Konop, T. Damps, A. Misicka, L. Rudnicka Certain Aspects of Silver and Silver Nanoparticles in Wound Care: A Minireview. Journal of Nanomaterials, vol. 2016, Article ID 7614753, 2016
  1. A. Lesniak, M. Bochynska-Czyz, M. Sacharczuk, S. Benyhe, A. Misicka, M. Bujalska-Zadrozny, A.W. Lipkowski Biphalin preferentially recruits peripheral opioid receptors to facilitate analgesia in a mouse model of cancer pain - A comparison with morphine. European Journal of Pharmaceutical Sciences, 2016, 89 (30), 39-49.
  1. P. Kleczkowska, E. Hermans, P. Kosson, A. Kowalczyk, A. Lesniak, K. Pawlik, E. Bojnik, S. Benyhe, B. Nowicka, M. Bujalska-Zadrozny, A. Misicka, A.W. Lipkowski Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile9]PK20 in an acute pain treatment in rodents. Brain Research, 2016, 1648, Part A, 172-180.
  1. A. Lesniak, Chaim G. Pick, A. Misicka, A. W. Lipkowski, M. Sacharczuk Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI). Neuropharmacology, 2016, 101, 506-518.
  1. O. Frączak, A. Lasota, D. Tymecka, P. Kosson, A. Muchowska, A. Misicka, A. Olma Synthesis, binding affinities and metabolic stability of dimeric dermorphin analogs modified with β3-homo-amino acids. J. Pept. Sci. 22(4), 222-227 (2016)
  1. M. Maciejczyk, A. Lasota, O. Frączak, P. Kosson, A. Misicka, M. Nowakowski, A. Ejchart, A. Olma The impact of β-azido(or 1-piperidinyl)methylamino acids in position 2 or 3 on biological activity and conformation of dermorphin analogues. J. Pept. Sci. 22(8):545-51 (2016).