Department of Neuropeptides

Head:

prof. Andrzej W. Lipkowski, PhD, DSc - This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Secretary:

Teresa Żuławnik - phone: +48 22 60 86 599

This email address is being protected from spambots. You need JavaScript enabled to view it.">tThis email address is being protected from spambots. You need JavaScript enabled to view it.

 

Research Staff:

prof. Aleksandra Misicka-Kęsik, PhD, Dsc - This email address is being protected from spambots. You need JavaScript enabled to view it.

prof. Lidia Rudnicka, PhD, Dsc, MD - This email address is being protected from spambots. You need JavaScript enabled to view it.

Barbara Kwiatkowska-Patzer, PhD, MD - phone: 22 60 86 545; This email address is being protected from spambots. You need JavaScript enabled to view it.

Piotr Kosson, PhD, VD - phone: 22 60 86 454; This email address is being protected from spambots. You need JavaScript enabled to view it.

Anna Lesniak, PhD - phone: 22 60 86 454, This email address is being protected from spambots. You need JavaScript enabled to view it.

Roman Wikłacz, MD - This email address is being protected from spambots. You need JavaScript enabled to view it.

PhD Students:

Marta Bochyńska, MSc - phone: 22 60 86 546/455, This email address is being protected from spambots. You need JavaScript enabled to view it.

Jolanta Dyniewicz, MSc, Ing - phone: 22 60 86 454, This email address is being protected from spambots. You need JavaScript enabled to view it.

Patrycja Kleczkowska, MSc, Ing - phone: 22 60 86 454; This email address is being protected from spambots. You need JavaScript enabled to view it.

Marek Konop MSc - This email address is being protected from spambots. You need JavaScript enabled to view it.

Joanna Matalińska, MSc, Ing - This email address is being protected from spambots. You need JavaScript enabled to view it.

Adriana Muchowska, MSc - phone: 22 60 86 454, This email address is being protected from spambots. You need JavaScript enabled to view it. (KNOW)

Tatsiana Kazlowa, MD - This email address is being protected from spambots. You need JavaScript enabled to view it. (KNOW)

Technicans:

Barbara Nowicka - phone: 22 60 86 480

Zdzisława Kowalska

 

Key Research themes:

Neuropeptides are endogenous peptides that are synthesized and released by neuronal cells. Released peptides express broad spectrum of functions including transmission and modulation of nervous signals,carrying neurohormonal signals to other body tissues, regulation of  immunological system activity, direct antimicrobial activities et cetera. Isolation of new neuropeptides and the knowledge of their biological functions has been significantly enhanced in recent years.  Limited biological barrier permeabilities, specific metabolism and structural flexibility are  specific biochemical and physico-chemical properties of peptides that differentiate them from other biologically active compounds. Their bio-pharmacological properties and cost of chemical syntheses for years limited interest in peptides as  potential medicines.  Recent progress in medicinal chemistry opens new avenue for development of new medicines based on neuropeptides. Peptides isolated and defined as neuropeptides are often identified in other body tissues as well. Therefore, name “endogenous regulatory peptides” are currently more suitable name for the group of compounds that are in focus of scientific interest of our group. Neuropeptide Department is an interdisciplinary group gathering biologists, chemists and medical doctors doing complementary work  on structure-activity relationships of peptides with final prospective application of results in development of new generation of medicines.

Role of neuropeptides in pain transmission and modulation and development of possible new methods of pain control  has been a major avenue of our scientific activities. Nevertheless, recent interest and activities of our group on peptides is broader and include:

  • role of blood-brain barrier;

  • peptides in cancer;

  • bioactivity of food derivatived peptides;

  • neuroprotection;

  • peptides in immunomodulation;

  • peptides in neurodegenerative diseases;

  • peptides in host-defensin systems;

  • peptides in skin functions and wound healing.

 

Current Collaborations:

  • Industrial Chemistry Research Institute, Warsaw, Poland

  • Institute of Organic Chemistry Polish Acad Sci, Warsaw, Poland

  • Faculty of Chemistry,Warsaw University, Warsaw Poland

  • Research Institute for Production Development, Kyoto, Japan (dr M. Yoshikawa)

  • Department of Chemistry, University of Arizona,Tucson, AZ-USA (prof.VJ Hruby)

  • Biological Research Instutute, Hungarian Acad Sci (dr. I. Krizbai, dr. G. Toth, dr. S. Benyhe)

  • Vrije Universiteit, Brussels, Belgium (prof. D. Tourwe)

  • Department of Pharmaceutical Sciences, University of Catania, Catania, Italy)

  • Pattern Expert, Borsdorf, Germany (O. Schroeder)

  • Instytut Homeostazy sp. z. o.o.,Warsaw, Poland

  • Institute of Biology, National Centre Sci Res “Demokritos”,  Athens, Greece(Dr. Z-I Georgoussi)

  • Steinbeis-Forschungs- und Entwicklungs-zentrum GmbH, Rostock, Germany (F. Graage)

  • Tufts-New England Medical Center, Boston, MA-USA (dr DB Carr)

  • Centrum Onkologii – Inst. M. Sklodowskiej-Curie, Warsaw (prof. S.Markowicz, dr J. Jarosz)

 

Selected Publications:

M. Kawalec, JE Kowalczyk, M Boresewicz, AW Lipkowski, B Zablocka, Neuroprotective potential of biphalin, multireceptor opioid peptide, against excititoxic injury In hippocampal organotypic culture. Neurochem. Res. 2011, 36 (11): 2091-2095).

Marta Kurzeja, Adriana Rakowska, Lidia Rudnicka1,2,3 and Malgorzata Olszewska, Criteria for diagnosing pemphigus vulgaris and pemphigus foliaceus by reflectance confocal microscopy. Skin Res Technol 2011; 1–8.

A. Lesniak, AW Lipkowski, Opioid peptides in peripheral pain control. Acta Neurobiol Exp (Wars) 71: 121-138 (2011).

M Sowinska, A Lesniak, AW Lipkowski, Z Urbanczyk-Lipkowska, Dendrimeric peptides with affinity to opioid receptors – complexation studies (M. Lebl, M Meldal, KJ Jensen, T Hoeg-Jensen, eds), Proc 31st Eur Pept Symp, Eur. Pep. Soc. 2010, 592-593.

P Kleczkowska, P Kosson, S Ballet, I Van den Eynde, Y Tsuda, D Tourwe, AW Lipkowski, PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects. Mol Pain. 2010 6; 86.

Y Yamada, K Ohinata, AW Lipkowski, M Yoshikawa Rapakinin, Arg-Ile-Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecyctokinin CCK2 receptor in mice. Peptides, 32; 281-285(2011).

M. Lazarczyk, E. Matyja, AW Lipkowski, A comparative study of morphine stimulation and biphalin inhibition of human glioblastoma T98G cell proliferation in vitro, Peptides 31, 1606-1612 (2010).

L Jaworska-Feil, D Jantas, M Leskiewicz, B Budziszewska, M Kubera, A Basta-Kaim, AW Lipkowski, W Lason,  Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells. Neuropeptides 44, 495-508 (2010).

M Sacharczuk, A Lesniak, M Korostynski, R Przewlocki, A Lipkowski, K Jaszczak, B Sadowski , A polymorphism in exon 2 of the d-opioid receptor affects nociception in response to specific agonists and antagonists in mice selectively bred for high and low analgesia Pain 149, 506-513 (2010).