Head:
Professor Agnieszka Pawlak, MD, PhD - phone 22 60 86 518; This email address is being protected from spambots. You need JavaScript enabled to view it.

Secretary:
Kiljańska Monika This email address is being protected from spambots. You need JavaScript enabled to view it.

Research Staff:
Ziemba Andrzej, PhD, Assoc. Prof - phone: +48 22 60 86 511 fax: +48 22 60 86 624, This email address is being protected from spambots. You need JavaScript enabled to view it.
Gil Robert, PhD, Assoc. Prof -  phone:. +48 22 60 86 518; This email address is being protected from spambots. You need JavaScript enabled to view it.
Kosior Dariusz, PhD, Assoc. Prof - phone: +48 22 60 86 518; This email address is being protected from spambots. You need JavaScript enabled to view it.
Niewiadomski Wiktor, PhD - phone:  +48 22 60 86 612; This email address is being protected from spambots. You need JavaScript enabled to view it.
Dorobek Małgorzata, PhD – phone: +48 22 60 86 518;
Zaleska Marzanna, PhD - phone +48 22 60 86 518; This email address is being protected from spambots. You need JavaScript enabled to view it.
Gąsiorowska Anna, PhD - phone: +48 22 60 86 612; This email address is being protected from spambots. You need JavaScript enabled to view it.
Krysztofiak Hubert MD, PhD - phone: +48 22 60 86 517; This email address is being protected from spambots. You need JavaScript enabled to view it.
Mikulski Tomasz, MD, PhD - phone: +48 22 60 86 517; This email address is being protected from spambots. You need JavaScript enabled to view it.
Górecka Monika, PhD - phone: +48 22 60 86 514;  This email address is being protected from spambots. You need JavaScript enabled to view it.
Kozacz Agnieszka,PhD - phone: +48 22 60 86 512; This email address is being protected from spambots. You need JavaScript enabled to view it.
Zagozda Małgorzata, PhD - phone: +48 22 60 86 518; This email address is being protected from spambots. You need JavaScript enabled to view it.

Technicial Staff:
Grabinska Alicja - phone: 22 60 86 518
Ziarkowska Jolanta - phone: 22 60 86 518

PhD students:
Patrycja Drapich, Msc, phone: 22 60 86 515 This email address is being protected from spambots. You need JavaScript enabled to view it.

General research profile:
Assessment of neurohormonal, hemodynamic, metabolic and thermoregulatory responses to physiological stimuli.
• Metabolic and hormonal responses to glucose intake and exercise in people on a high-fat diet.
• Metabolic and hormonal responses to glucose intake and exercise in people with hyperthyroidism and hypothyroidism.
• Modification of the central fatigue processes with the use of amino acid nutritional supplements.
• The impact of hypoxic (altitude) training on psychomotor performance
• Cardiovascular reactions to a short Valsalva maneuver at rest and during strength exercise.
• Comparison of non-invasive methods of assessing the activity of the sympathetic nervous system in humans.
• Non-invasive methods of continuous assessment of cardiovascular function in laboratory tests.
• The role of angiopoietin-like ANGPTL 3 and 4 proteins in the regulation of lipid metabolism during moderate-intensity exercise.
• Changes in the activity of lipoprotein lipase and lipid metabolism in muscles under the influence of hormonal factors and exercise (in animals).

Current research projects:
• Grant: 2014/13 / B / N24 / 03832 - project manager: prof. Robert Gil "Identification of viruses and assessment of ultrastructural changes accompanying the presence of the virus in the heart muscle tissue in patients with suspected post-inflammatory dilated cardiomyopathy"

Apparatus available:

• Tecan Spark 10M multi-sensing microplate reader
• T2000 treadmill
• Cycloergometers (Monark, Siemens)
• Ergospirometry (Medgraphics, Sensormedics Vmax 29)
• Apparatus for psychomotor tests: differential reaction time, Piórkowski / Cross test, spinning disc test, distance evaluation apparatus)
• Vibrating platform
• System for continuous blood pressure measurement (Portapres)
• Ultrasonic homogenizer model 150 V / T (Biologics Inc)
Research methods
• Direct measurements metabolic rate in humans. (basal, in resting and during physical exercise) based of oxygen uptake and carbon dioxide production
• Aerobic and anaerobic exercise testing.
• Psychomotor performance testing.
• Direct measurement of the sweating rate during exercise.
• Blood sampling during exercise – influence of nutrients on exercise capacity.
• Field exercise testing.
• Hypoxic training.
• Body composition analysis.
• Rest and exercise echocardiography
• Holter ECG analysis
• Pressure RR Holter analysis
• Analysis of ultrastructural changes in tissues
• Analysis of the cytokine profile
• Biochemical analyzes by enzyme immunoassay (ELISA)
• Glucose load test (OGTT)
• Continuous measurement of the stroke and minute volume of the heart, the maximum stroke velocity and the duration of the left ventricular systole periods using the electrical impedance method.
• Continuous blood pressure measurement by plethysmography.
• Tonometry
• Lymphoscntygraphia
• Doppler technique

Selected publications:

• Agnieszka Kozacz 1,Gilmara Gomes de Assis1,Urszula Sanocka, Andrzej Wojciech Ziemba1Standard hypothyroid treatment did not restore proper metabolic response to carbohydrate  Received: 17 February 2020 / Accepted: 27 April 2020 The Author(s) 2020 
• Kosior DA, Undas A, Kopeć G, Hryniewiecki T, Torbicki A, Mularek-Kubzdela T, Windyga J, Pruszczyk P. Guidance for anticoagulation management in venous thromboembolism during the coronavirus disease 2019 pandemic in Poland: an expert opinion of the Section on Pulmonary Circulation of the Polish Cardiac Society. Kardiol Pol. 2020 Jun 25;78(6):642-646. doi: 10.33963/KP.15425. Epub 2020 Jun 8.
• Jankowski P, Kosior DA, Sowa P, Szóstak-Janiak K, Kozieł P, Krzykwa A, Sawicka E, Haberka M, Setny M, Kamiński K, Gąsior Z, Kubica A, De Bacquer D, De Backer G, Kotseva K, Wood D, Pająk A, Czarnecka D. Secondary prevention of coronary artery disease in Poland. Results from the POLASPIRE survey. Cardiol J. 2020 May 21. doi: 10.5603/CJ.a2020.0072. Epub ahead of print.
• Biernacka EK, Kosior DA, Zienciuk-Krajka A, Miszczak-Knecht M, Kempa M, Przybylski A. Safety of antiviral and anti-inflammatory drugs prolonging QT interval in patients with coronavirus disease 2019: an opinion of the Heart Rhythm Section of the Polish Cardiac Society. Kardiol Pol. 2020 May 25;78(5):493-497. doi: 10.33963/KP.15354. Epub 2020 May 11.
• Kalińska I, Kułak P, Szymańska UA, Walecki J, Kosior DA. Treat the vessel, save the heart: a rare case of spontaneous sensitive carotid artery dissection. Kardiol Pol. 2020 May 25;78(5):478-479. doi: 10.33963/KP.15269. Epub 2020 Mar 31.
• Kalińska I, Kułak P, Szymańska UA, Walecki J, Kosior DA. Parasympathetic denervation as an alternative to permanent pacing. Authors' reply. Kardiol Pol. 2020 Jun 25;78(6):613. doi: 10.33963/KP.15455. Epub 2020 Jun 25.
• Maciej Haberka, Piotr Jankowski, Dariusz A. Kosior, Małgorzata Szpakowicz, Karolina Szóstak-Janiak, Paweł Kozieł, Agnieszka Krzykwa, Magda Łapińska, Małgorzata Setny, Karol Kamiński, et al. Treatment goal attainment for secondary prevention in coronary patients with or without diabetes mellitus : Polish multicenter study POLASPIRE ARCHIVES OF MEDICAL SCIENCE, 2020, doi:10.5114/aoms.2020.92558.
• Ferrannini G, De Bacquer D, De Backer G, Kotseva K, Mellbin L, Wood D, Rydén L; EUROASPIRE V collaborators. Screening for Glucose Perturbations and Risk Factor Management in Dysglycemic Patients With Coronary Artery Disease-A Persistent Challenge in Need of Substantial Improvement: A Report From ESC EORP EUROASPIRE V. Diabetes Care. 2020 Apr;43(4):726-733. doi: 10.2337/dc19-2165. Epub 2020 Feb 20. PMID: 32079627.
• Marques-Vidal P, Jankowski P, De Bacquer D, Kotseva K; EUROASPIRE V collaborators. Dietary measures among patients with coronary heart disease in Europe. ESC EORP Euroaspire V. Int J Cardiol. 2020 Mar 1;302:5-14. doi: 10.1016/j.ijcard.2019.12.064. Epub 2019 Dec 31.
• Hudzik B, Budaj A, Gierlotka M, Witkowski A, Wojakowski W, Zdrojewski T, Gil R, Legutko J, Bartuś S, Buszman P, Dudek D, Gąsior M. Assessment of quality of care of patients with ST-segment elevation myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2019 Nov 25:2048872619882360. doi: 10.1177/2048872619882360. Epub ahead of print.
• Zimarino M, Barbato E, Nakamura S, Radico F, Di Nicola M, Briguori C, Gil RJ, Kanic V, Perfetti M, Pellicano M, Mairic K, Stankovic G; European Bifurcation Club. The impact of the extent of side branch disease on outcomes following bifurcation stenting. Catheter Cardiovasc Interv. 2020 Jul;96(1):E84-E92. doi: 10.1002/ccd.28842. Epub 2020 Mar 9.
• Górecka M, Krzemiński K, Buraczewska M, Kozacz A, Dąbrowski J, Ziemba AW. Effect of mountain ultra-marathon running on plasma angiopoietin-like protein 4 and lipid profile in healthy trained men.  Eur J Appl Physiol. 2019 Nov 9.IF=3,055; MNiSW=100 pkt.; Q1
• Zaleska MT, Olszewski WL, Ziemba AW, Mikulski T., The Neglected Leg Lymphatic Vascular Changes in the Pathomechanism of Delayed Onset Muscle Soreness in Runners., Lymphat Res Biol. 2019 Sep 10. doi: 10.1089/lrb.2019.0012. [Epub ahead of print] (praca oryginalna).
• Pawlak A, Rejmak-Kozicka E, Gil KE, Ziemba A, Kaczmarek L, Gil RJ. Patterns of desmin expression in idiopathic dilated cardiomyopathy are related to the desmin mRNA and ubiquitin expression. J Investig Med. 2019 Jan;67(1):11-19. doi: 10.1136/jim-2017-000707.
• Anna Stępniewska, Monika Budnik, Krzysztof Krzemiński, Wiktor Niewiadomski, Anna Gąsiorowska, Grzegorz Opolski, Janusz Kochanowski, Katarzyna Mieczkowska, Katarzyna Żukowska, Katarzyna Szepietowska, Robert Kowalik. Impaired hemodynamic response to tilt, handgrip and Valsalva manoeuvre in patients with takotsubo syndrome. Autonomic Neuroscience: Basic and Clinical,Volume 220, September 2019, 102555, https://doi.org/10.1016/j.autneu.2019.
• Dąbrowski J, Czajka A, Zielińska-Turek J, Jaroszyński J, Furtak-Niczyporuk M, Mela A, Poniatowski ŁA, Drop B, Dorobek M, Barcikowska-Kotowicz M, Ziemba A: Brain Functional Reserve in the Context of Neuroplasticity after Stroke. Neural Plast. 2019 Feb 27;2019:97
• Gilmara Gomes de Assis  “BDNF and Neurodegeneration: The Rise of the Exercise as a Preventive Care”
• Jarosław Krzywański,  Tomasz Mikulski  , Andrzej Pokrywka  , Marcel Młyńczak , Hubert Krysztofiak, Barbara Frączek  and Andrzej Ziemba . Vitamin B12 Status and Optimal Range for Hemoglobin Formation in Elite Athletes.
• Jarosław Krzywański ,  Andrzej Pokrywka , Marcel Młyńczak ,   Tomasz  Mikulski . Is vitamin D status reflected by testosterone concentration in elite athletes? 
• Jarosław Krzywański PhD, Ernest Kuchar PhD, Andrzej Pkrywka PhD, Tomasz Mikuski PhD, Iwona Pilchowska MSc, Marcel Młyńczak PhD, Hubert Krysztofiak PhD, Janusz Jurczyk MD, Andrzej Ziemba PhD, Aneta Nitsch-Osuch PhD. Safety and Impact on Training of the Influenza Vaccines Elite Athletes Participating in the Rio 2016 Olympics. Clin J Sport Med 2020 Feb 6. doi: 10.1097/JSM.0000000000000808. Online ahead of print.
•  De Assis GG, Gasanov EV, de Sousa MBC, Kozacz A, Murawska-Cialowicz E. Brain derived neutrophic factor, a link of aerobic metabolism to neuroplasticity. J Physiol Pharmacol. 2018 Jun;69(3). doi: 10.26402/jpp.2018.3.12. Epub 2018 Oct 18.
• Krysztofiak, H; Malek, LA, Mlynczak, M; Braksator, W. Comparison of echocardiographic linear dimensions for male and female child and adolescent athletes with published pediatric normative data. PLOS ONE, 2018,
• Mlynczak,M; Krysztofiak,H.Discovery of Causal Paths in Cardiorespiratory Parameters: A Time-Independent Approach in Elite Athletes. FRONTIERS IN PHYSIOLOGY, 2018: 9 
• Pawlak A, Rejmak-Kozicka E, Gil KE, Ziemba A, Kaczmarek L, Gil RJ.  Patterns of desmin expression in idiopathic dilated cardiomyopathy are related to the desmin mRNA and ubiquitin expression.. J Investig Med. 2018, 10.
• Wiligorska N, Wiligorska D, Frontczak-Baniewicz M, Przybylski M, Krzyzewski R, Ziemba A, Gil RJ. Pawlak A, Viral Heart Disease and Acute Coronary Syndromes - Often or Rare Coexistence? Curr Pharm Des. 2018;24(4):532-540
• Pawlak A., Wiligorks a N, Wiligorksa D, Frontczak Baniewiczk M., Pryszbylski M, Krzyżewski  R. Ziemba A, Gil RJ. Yral heart disease and acute coronary syndrome – often to rare coeexistense. Curr Parm. Des. 2017
• Eyileten C, Zaremba M, Janicki PK, Rosiak M, Cudna A, Kaplon-Cieslicka A, Opolski G, Filipiak KJ, Kosior DA, Mirowska-Guzel D, Postuła M. Serum brain-derived neurotrophic factor is related to platelet reactivity in patients with type 2 diabetes. Med Sci Monit, 2016; 22: 69-76
• Gorecka M, Synak M, Brzezinska Z, Dabrowski J, Zernicka E: Effect of triiodothyronine (T3) excess on fatty acid metabolism in the soleus muscle from endurance-trained rats. Biochem Cell Biol. 2016 Apr;94(2):1 01 -8. IF= 2,153 
• Krzemiński K, Buraczewska M, Miśkiewicz Z, Dąbrowski J, Steczkowska M, Kozacz A, Ziemba A. Effect of ultra-endurance exercise on left ventricular performance and plasma cytokines in healthy trained men. Biol Sport. 2016; 33(1): 63-69
• Krzywanski J, Mikulski T, Krysztofiak H, Mlynczak M, Gaczynska E, Ziemba A.: Seasonal Vitamin D Status in Polish Elite Athletes in Relation to Sun Exposure and Oral Supplementation. PLoS One. 2016 ;11(10)12
• Mikulski T, Dąbrowski J, Hilgier W, Ziemba A, Krzeminski K. Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men. Folia Neuropathol. 2015; 53(4): 377-386
• Niewiadomski W, Strasz A, Mróz A, Laskowska D, Langfort J, Gąsiorowska A. Effect of type of static exercise and whole body vibration frequency on oxygen consumption and respiratory activity in young and middle-aged women. Arch Budo 2015; 11 259-264