Mossakowski Medical Research Institute

Polish Academy of Sciences

in Warsaw

is looking for

a POST-DOC in the Laboratory of Immunology

Deadline for applications: 20th March, 2024

Procedure ID: PI.110.4.2024

Expected starting date: April 2024

Institute website: www.imdik.pan.en

Laboratory website:

We are recruiting to the OPUS project No. 2023/49/B/NZ7/03915 entitled "Unraveling protease activation in stimulated CAR-T cells to identify new biomarkers for assessing their clinical efficacy" funded by the National Science Centre and carried out at the Laboratory of Immunology at the Mossakowski Medical Research Institute Polish Academy of Sciences (MMRI PAS). The project is led by Dr. Małgorzata Firczuk. The Laboratory of Immunology is a new, rapidly developing scientific unit at MMRI PAS, bringing together young scientists and collaborating with numerous clinical and research teams in Poland and abroad. Currently, the Laboratory is implementing twelve projects funded by external agencies. We are looking for a candidate with a genuine passion for research, enthusiasm for discoveries, and a commitment to advancing scientific knowledge.

Information about the research project in which the candidate would participate:

Cell therapy using T cells modified with chimeric antigen receptors (CAR-T) is a novel and groundbreaking method for treating the most challenging cases of hematologic cancers, already applied in clinics, also in Poland. The project's goal is to identify new biomarkers for monitoring the effectiveness of CAR-T cell therapy. In particular, we will investigate proteases activated in CAR-T cells after their contact with tumor cells. In collaboration with the team led by Dr. Marcin Poręba from Wrocław University of Science and Technology, a partner in the project, we plan to develop probes enabling a precise assessment of protease activity using flow cytometry and mass cytometry. It is worth emphasizing that, while the project focuses on basic research to enhance our understanding of the mechanisms of CAR-T cell activation, the results obtained also carry translational and commercialization potential.

Description of duties:

• planning and conducting experiments

• creative work involving the analysis of current literature and initiating changes during project implementation

• analysis and interpretation of acquired data

• maintaining documentation of research results following FAIR principles

• presenting results at seminars within the Laboratory and the Institute, as well as at broader scientific forums, including national and international scientific conferences

• coordinating the work of students

• writing scientific publications

Requirements for the candidate:

• Ph.D. degree in biological/medical/pharmaceutical/chemical sciences or a related field

• experience with laboratory work in the areas of biochemistry, molecular biology, experimental oncology, or immunology

• scientific achievements documented by international publications in journals indexed in the JCR list

• documented active participation in national and international conferences and symposiums

• proficiency in spoken and written English

• excellent organizational skills and attention to detail

• ability to work independently and as a part of a team, strong communication skills

We offer:

• a full-time employment contract for a period of up to 4 years

• a salary of approximately 9000 PLN gross per month

• innovative research challenges and unique opportunities for developing research skills

• freedom and independence in carrying out assigned tasks

• mentoring and support in professional career development

• friendly, inspiring, and supportive work environment within the large team of the Laboratory of Immunology

• opportunity to present research results at scientific conferences

• support in publishing and promoting research findings

• benefits package, including a Multisport Plus card and the option to participate in group insurance on preferential terms

Please submit the following documents:

• motivation letter containing information about scientific interests, research work, and explaining why you want to work on the project

• CV (signed by the candidate) in .pdf format

• copy of the diploma confirming the academic degree

• at least one letter of recommendation from the current or former supervisor/academic advisor

Apply via email to the project PI: This email address is being protected from spambots. You need JavaScript enabled to view it., deadline for sending the application is

20th March 2024. In the email title please include: „Post-doc” and procedure ID: PI.110.4.2024

Deadline for applications: 20th March, 2024

Expected starting date: April 2024

Applications submitted after the deadline will not be considered. We reserve the right to invite only selected candidates for interviews.


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